Biologics News

Patients with rheumatoid arthritis who fail their first JAK inhibitor can achieve success with either “cycling” to another JAK inhibitor or switching to a biologic disease-modifying antirheumatic drug, according to data presented at ACR Convergence 2021.

In an extension of the REDO trial, most patients with rheumatoid arthritis on ultra-low-dose rituximab — either 200 or 500 mg — maintained low disease activity for up to 4 years, according to data presented at ACR Convergence 2021.

Compared with placebo injections, intra-articular platelet-rich plasma injections did not significantly improve function or relieve symptoms in patients with ankle osteoarthritis, according to published results.

Initial biologic therapy is now the most common treatment for children with systemic juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry, according to data presented at ACR Convergence 2021.

Early, aggressive treatment with a biologic alongside a conventional DMARDs for juvenile idiopathic arthritis achieved clinically inactive disease at 24 months more frequently than other strategies, said a presenter at ACR Convergence 2021.

Abatacept is superior to placebo in improving subclinical inflammation in patients who are at high risk for rheumatoid arthritis, and in slowing arthritis progression, at 6 months, according to data presented at ACR Convergence 2021.

In this video from the American Academy of Orthopaedic Surgeons Orthobiologics Symposium, Scott A. Rodeo, MD, FAAOS, spoke on the potential of cell and blood-based orthobiologics injectables for patients with osteoarthritis.

According to published results, intra-articular orthobiologics injections are a safe and effective treatment with positive outcomes in patients undergoing high tibial osteotomy for knee osteoarthritis.

In this video from the American Academy of Orthopaedic Surgeons Orthobiologics Symposium, Kenneth R. Zaslav, MD, FAAOS, offered advice on how to integrate the use of orthobiologic injections safely and efficiently into practices.

Published results showed an association between hip corticosteroid injections and rapidly destructive hip disease.