Extended oral antibiotics may predict lower failure rates in treatment of PJI after TKA
Click Here to Manage Email Alerts
Key takeaways:
- Primary antibiotics plus extended oral antibiotics was associated with reduced failure vs. isolated primary antibiotics.
- There was no significant difference in the rates of adverse events between the two groups.
Results presented at the Musculoskeletal Infection Society Annual Meeting showed combined primary and extended oral antibiotics may predict lower treatment failure rates for periprosthetic joint infection after total knee arthroplasty.
Kenneth L. Urish, MD, PhD, associate medical director of the Magee Bone and Joint Center at the University of Pittsburgh Medical Center, and colleagues performed a prospective cohort study following 74 patients who underwent a debridement, antibiotics and implant retention procedure for PJI following TKA. Patients were categorized into groups depending on whether they received isolated primary antibiotics (n = 39) or both primary and extended oral antibiotics (n = 35) for 1 year. Outcomes measured included treatment failure rate and drug-related adverse events.
According to Urish, patients who received primary antibiotics combined with extended oral antibiotics had a significantly reduced rate of treatment failure vs. those who received isolated primary antibiotics (HR = 0.46).
Urish also said there was no significant difference in the rates of adverse events between patients who received isolated primary antibiotics vs. primary antibiotics combined with extended oral antibiotics.
“This [study] was prospective. This was like a baby step in preparation,” Urish said.
He added, “We need to do a randomized open label study and have centers of excellence, and it becomes much easier to do these types of things.”
Collapse
Urish KL, et al. Paper 1229. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug. 2-3, 2024; Durham, North Carolina (hybrid meeting).
Click Here to Manage Email Alerts