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February 12, 2024
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Cannabidiol may be effective pain control treatment following arthroscopic cuff repair

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Key takeaways:

  • Patients receiving cannabidiol showed no patient-reported differences vs. a placebo group.
  • The cannabidiol group also showed no significant differences in complications vs. the placebo group.

SAN FRANCISCO — According to results presented here, cannabidiol may be effective in perioperative pain control for patients who previously underwent arthroscopic rotator cuff repair.

“Patients utilizing buccally absorbed cannabidiol and postoperative multimodal regimen following arthroscopic cuff repair had absolutely no differences in patient-reported outcomes compared to the placebo group at 1-year follow-up,” Michael J. Alaia, MD, FAAOS, said in his presentation at the American Academy of Orthopaedic Surgeons Annual Meeting.

OT0224Alaia_AAOS_Graphic_01
Data were derived from Alaia MJ, et al. Paper 9. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; Feb. 12-16, 2024; San Francisco.

Alaia and colleagues at NYU Langone randomly assigned patients who previously underwent arthroscopic rotator cuff repair to receive either buccally absorbed cannabidiol or an identical placebo three times daily in the early postoperative period.

Michael J. Alaia
Michael J. Alaia

Outcome measures included VAS pain scores, American Shoulder and Elbow Surgeons scores, single assessment numeric evaluation functionality scores and patient satisfaction scores.

Overall, Alaia and colleagues found no significant differences in patient-reported outcomes between patients receiving a placebo vs. cannabidiol.

In addition, Alaia said that patient satisfaction and the percentage of patients who reported a willingness to repeat the surgery was more than 95% in both groups.

He also said there was not a significant difference in complication rates between the groups, with the cannabidiol group having one secondary procedure after index surgery and the placebo group having two.

“Looking at further directions for our group, we are currently looking at knee osteoarthritis in a controlled randomized trial,” Alaia said. “We are going to see if this has any impact on synovial biomarkers, particularly after ACL injury or chronic knee pain, as well as what is the optimal strategy for these patients.”