Iodine povacrylex shows similar infection, reoperation rates as chlorhexidine gluconate
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Key takeaways:
- Patients who received iodine povacrylex had no differences in risk for surgical site infection vs. those who had a chlorhexidine gluconate solution.
- Both groups showed no differences in unplanned reoperations.
SEATTLE — Data presented here showed patients with open fractures treated with iodine povacrylex in had similar risks for surgical site infection and unplanned reoperation as those who had a chlorhexidine gluconate solution.
Gerard P. Slobogean, MD, MPH, and colleagues randomly assigned 22 hospitals in the U.S. and Canada to use either an iodine povacrylex or chlorhexidine gluconate antiseptic solution during debridement and surgical fixation of patients with open fractures of the lower or upper extremity (n=1,651; mean age, 45 years). During the initial 2 months of recruitment, each site used the assigned antiseptic solution before switching to the opposite antiseptic, alternating between the solutions every 2 months, according to the abstract. Researchers considered surgical site infection within 90 days as defined by CDC criteria as the primary outcome measure and unplanned reoperation within 1 year as the secondary outcome measure.
Slobogean said patients treated with iodine povacrylex had no differences in rates of surgical site infections compared with patients treated with chlorhexidine gluconate.
He also said the two groups had no differences in unplanned reoperation rates at 1 year.
“Should we consider a policy change to use iodine povacrylex for all of our fracture surgery, because we know it reduces infections in closed fractures, it is certainly not harmful for open fractures and it may even benefit open fractures?” Slobogean said.
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Slobogean GP, et al. Paper 89. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 18-21, 2023; Seattle.
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