High tibial osteotomy with pure PRP may improve outcomes at 1 year in knee OA
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Patients with knee osteoarthritis who underwent high tibial osteotomy combined with intra-articular pure platelet-rich plasma had improved clinical and functional outcomes during the first postoperative year, according to published results.
Researchers randomly assigned 80 patients with knee OA matched for preoperative age, sex and BMI to undergo high tibial osteotomy alone (n=41) or with intra-articular pure-PRP (n=39). Researchers collected VAS score, WOMAC score and Lysholm score, and measured the minimum width of medial knee joint, medial proximal tibial angle, femoral tibial angle and weightbearing line preoperatively, immediately postoperatively and at 1, 6, 12 and 24 months postoperatively.
Results showed patients in the high tibial osteotomy plus pure-PRP group had better pain and function scores at 1, 6 and 12 months postoperatively compared with patients who received high tibial osteotomy alone. Researchers found this difference between groups was highest at 6 months in Lysholm and WOMAC scores. Researchers noted no differences in preoperative and postoperative femoral tibial angle and weightbearing line between the two groups. During the first year, patients in the high tibial osteotomy plus pure-PRP group had a significantly greater increase in the minimum width of medial knee joint vs. high tibial osteotomy alone, especially at 6 months, according to results.
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