IL-6, neutrophil-to-lymphocyte ratio may predict patient outcomes of TKA for OA
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Interleukin-6 and neutrophil-to-lymphocyte ratio may be used as preoperative risk stratifying tools among patients undergoing total knee arthroplasty for osteoarthritis, according to results presented at the Virtual EFORT Congress.
Amit Chawla, MBBS, MRCS, and colleagues measured serum IL-6, tumor necrosis factor-alpha, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio preoperatively, postoperatively and on day 1 and day 3 postoperatively among 50 patients undergoing TKA for OA.
“[Patient-reported outcome measures] PROMs were measured at 12 months postoperatively using the Oxford Knee Score and EuroQol-5D questionnaire,” Chawla said in his presentation.
Chawla noted IL-6 increased to day 1 postoperatively and decreased to day 3 postoperatively, while tumor necrosis factor-alpha increased across all time points.
“[Platelet-to-lymphocyte ratio] PLR and [neutrophil-to-lymphocyte ratio] NLR followed a similar pattern to IL-6,” Chawla said.
Regression analysis showed preoperative IL-6 had a significant negative correlation with 12-month Oxford Knee Score, according to Chawla. He added preoperative NLR, 12-month Oxford Knee Score and 12-month EQ-5D had a significant positive correlation.
“This is an exploratory study and, if the findings are replicated elsewhere, this raises the possibility to use IL-6 or NLR as a preoperative risk stratification tool or to develop interventions to optimize patients using these biomarkers as markers of effectiveness,” Chawla said. “Further research is necessary, ideally in the form of an adequately powered prospective study, to further investigate these mechanisms.”
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Chawla A, et al. Paper 867. Presented at: Virtual EFORT Congress; Oct. 28-30, 2020.
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