Lower mortality, complication rates seen with extended DVT prophylaxis for hip fracture surgery

ORLANDO, Fla. — Patients who underwent hip fracture surgery and were prescribed deep vein thrombosis prophylaxis for 28 days or more had a 67% lower chance of death and significantly lower stoke/cerebrovascular and acute kidney injury rates compared with patients prescribed short-duration prophylaxis, according to a presenter at the Orthopaedic Trauma Association Annual Meeting.

“[Based] on the data we have, we believe that there is some kind of benefit in extended DVT prophylaxis ... ” Joseph Johnson, MD, said during his presentation.

Johnson and colleagues used the American College of Surgeons National Surgical Quality Improvement Program hip fracture procedure-targeted dataset to identify 7,533 patients who were surgically treated for hip fractures. There were 57.8% of patients who were prescribed extended DVT prophylaxis. Patients who received no prophylaxis and patients who received short-duration prophylaxis were included in a control group. Among the outcome measures were death, the occurrence of postoperative complications, complication subtype, readmission or reoperation within 30 days after surgery, and length of stay. DVT prophylaxis continued for 28 days postoperatively was the primary independent variable.

Results from bivariate analysis showed an association between prescription of extended DVT prophylaxis and a lower incidence of death and stroke/cerebrovascular accidents. Investigators noted multivariate analysis demonstrated prescription of extended DVT prophylaxis correlated with lower odds of death and AKI. – by Monica Jaramillo

Reference:

Durand W, et al. Paper 93. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 18-20, 2018; Orlando, Florida.

Disclosure: Johnson reports no relevant financial disclosures.