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Highly porous collagen implant induced tendon-like tissue in partial-thickness rotator cuff tears
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Use of a highly porous collagen implant induced new tendon-like tissue formation in patients with partial-thickness rotator cuff tears, according to results.
Researchers attached a highly porous collagen implant (Rotation Medical Inc.) to the bursal surface of the supraspinatus tendon in 13 patients with intermediate- to high-grade partial-thickness rotator cuff tears. Researchers evaluated tendon thickness, defect size and tendon quality by MRI preoperatively at and 3 months, 6 months, 12 months and 24 months, while Constant and American Shoulder and Elbow Society (ASES) scores were used to assess clinical outcomes.
Results showed a significant increase in new tissue induction over the bursal surface of the supraspinatus tendon 3 months following surgery. Researchers noted a stable increase and progressive maturation of the implant during a span of 9 months, with a slight decrease in tendon thickness between 12 months and 24 months. However, compared with preoperative measures, researchers found the tendons remained significantly thicker.
According to results, 10 patients with measureable preoperative tear sizes had a progressive filling-in of the defects; with complete disappearance of the tear demonstrated by seven patients; and partial filling-in of defects demonstrated in three patients at 12 months. Throughout the 24-month follow-up period, results showed steady improvement on Constant and ASES scores.
“Partial-thickness rotator cuff tears frequently enlarge due to increased local strain and often progress to full-thickness tears,” Desmond John Bokor, MB, BS, MHEd(Med), FRACS, FAOrthA, associated professor in the Department of Orthopaedic Surgery at Macquarie University in Australia, said in a press release. “The results of this study demonstrate the ability of bioinductive implant to induce new tendon-like tissue, enabling partial-thickness rotator cuff tears to decrease in size and in most cases disappear. The ability to heal partial-thickness rotator cuff tears, and thus prevent tear propagation and progressive tendon degeneration, represents a novel interventional treatment paradigm for these lesions.” – by Casey Tingle
Disclosure: The researchers consultancy fees from Rotation Medical. CVK is also an employee of Rotation Medical.
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