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Aseptic loosening, OA progression cited as common causes of failure in UKA
Recently published results showed the most common causes of failure in medial unicompartmental knee arthroplasty included aseptic loosening and osteoarthritis progression.
In a search of PubMed, EMBASE and Cochrane databases and annual registries, researchers identified 37 cohort studies and two registry-based studies that reported either more than 25 unicompartmental knee arthroplasty (UKA) failures or early, midterm or late failures.
Researchers identified 3,967 overall failures, 388 time-dependent failures and 1,305 implant design failures. Results showed aseptic loosening and progression of osteoarthritis (OA) were the most common modes of failure at 36% and 20%, respectively. Aseptic loosening (25%), progression of OA (20%), bearing dislocation (17%), pain (8%), infection (7%) and tibial subsidence (7%) were identified as the most common reasons for early failures, according to results. Researchers also identified progression of OA as the most common cause of midterm (38%) and late failures (40%), and aseptic loosening (29%) and polyethylene wear (10%) as the most common modes of failure in the late phase.
When it came to fixed-bearing and mobile-bearing failures, results showed instability and polyethylene wear were more common failure modes for fixed-bearing implants, while unexplained pain and bearing dislocation were more common failure modes for mobile-bearing implants. – by Casey Tingle
Disclosures: van der List reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.