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Patients with progressive hand OA also at risk for knee OA progression
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In this study, progression of hand osteoarthritis was linked to a stronger likelihood of knee osteoarthritis progression in patients who participated in the Genetics, Arthrosis and Progression sibling pair cohort study.
“Progression of hand [osteoarthritis] OA clusters between hand joint groups, especially between [interphalangeal] IP joints, and within sibling pairs … is associated with OA change at the knee,” the researchers, who are from The Netherlands, wrote in their study abstract.
“These findings contribute to defining hand OA subsets and suggest a role for systemic factors,” they wrote.
The researchers analyzed 6 years of radiographs for osteoarthritic progression in 236 patients with hand OA using the Osteoarthritis Research Society International atlas, defining radiographic progression as changes in osteophytes and joint space narrowing, according to the abstract.
Distal IP (DIP), proximal IP (PIP), IP-1 and carpometacarpal (CMC-1) radiographic progression clustering were assessed using the chi-squared test.
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Upon analysis of the test results, the researchers found greater OA progression in DIP, PIP and IP-1 joints, according to the abstract. Other signs of hand OA progression they found included symmetry and clustering by row, but not clustering by ray. The researchers observed familial aggregation of hand OA progression and noted that patients whose hand OA progressed had a higher risk for radiographic change in their knee OA than patients who did not have progression of hand OA.
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