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Positive surgical margins linked with adverse survival-related outcomes in soft tissue sarcoma patients
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Positive surgical margins are significantly associated with adverse survival and related outcomes in patients with extremity soft tissue sarcomas, according to results of this study.
“The current study demonstrates that primary tumor size of greater than 10 cm and positive surgical resection margins are consistently significant indicators of adverse disease-related outcomes including local and distant disease failure, disease-specific survival, and overall survival,” Benjamin K. Potter, MD, and colleagues wrote in the study. “Local recurrence had a significant impact on overall survival, but was not significantly associated with disease-specific survival on multivariate analysis.”
In the retrospective analysis, Potter and colleagues evaluated 363 patients from the United States Department of Defense Automated Central Tumor Registry who underwent resection of a local extremity soft tissue sarcoma, according to the abstract. The researchers measured overall survival, disease-specific survival, outcomes for local recurrence and distant recurrence using Kaplan-Meier and Cox regression analyses.
In addition to finding a significant association between positive surgical margins and adverse survival-related outcomes, they found local recurrence impacted overall survival, but not disease-specific survival. Independent prognostic factors included distant recurrence, tumor size greater than 10 cm and positive margins with regard to disease-specific survival, according to the abstract.
Disclosure: The authors received institutional support from the United States Military Cancer Institute for their work on this study.
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