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Higher risk of medial end-stage OA found in patients with constitutional varus
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CHICAGO — Patients with constitutional varus had a higher risk of developing medial end-stage osteoarthritis, according to a presenter here.
“Constitutional varus significantly contributes to varus osteoarthritis,” P-J Vandekerckhove, MD, said in his presentation at the International Cartilage Repair Society Annual Meeting. “Patients with constitutional varus seem to be more at risk in developing end-stage OA, and this population seems to be a target population for early OA and possible preventive strategies.”
Among 315 patients with unilateral end-stage medial osteoarthritis of the knee, Vandekerckhove and colleagues made a correlation in the coronal plane between medial end-stage OA and the contralateral non-arthritic side.
The researchers performed an analysis of the mechanical lateral distal femoral angle, the medial proximal tibial angle and the joint line conversation angle to determine the knee joint line orientation. Results were compared between the overall population, the male population and the female population.
Vandekerckhove noted patients with more osteoarthritis had a higher rate of constitutional varus. When comparing this result between men and women, results showed a progressive contribution of constitutional varus with more OA among men.
“If you look in men on the osteoarthritic side of more than 6°, up to 60% of men had constitutional varus,” Vandekerckhove said. “In patients who had more than 12° of varus, the constitution was even 100%.” – by Casey Tingle
Reference:
Vandekerckhove P, et al. The relationship between constitutional alignment and varus osteoarthritis of the knee in males and females. Presented at: International Cartilage Repair Society Annual Meeting. May 8-11, 2015; Chicago.
Disclosure: Vandekerckhove reports no relevant financial disclosures.