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Single injection of Hydros, Hydros-TA can relieve pain from knee OA
Pain associated with knee osteoarthritis was relieved with a single injection of Hydros or Hydros-TA, according to study results.
Researchers randomly assigned 98 participants with knee osteoarthritis (OA) to receive one 6-ml intra-articular injection of either Hydros (hyaluronan-based hydrogel suspended in hyaluronan solution, Carbylan BioSurgery), Hydros-TA (hyaluronan plus 10 mg of triamcinolone acetonide [TA], Carbylan BioSurgery) or Synvisc-One (hylan G-F 20, Sanofi-Aventis). The researchers evaluated patients at 2, 6, 13 and 26 weeks post-treatment and assessed safety from adverse events at all visits. The change from baseline on the WOMAC pain score for the treatment knee was the study’s primary outcome.
Results showed similar adverse events across all treatment groups, with arthralgia, joint swelling, back pain and joint stiffness being the most common. According to the researchers, arthralgia was reported five times in the hylan G-F 20 treatment group, four times in the Hydros treatment group and one time in the Hydros-TA treatment group.
During the course of 26 weeks, the researchers observed a reduction in WOMAC pain scores of 30.5 mm for Hydros, 34.4 for Hydros-TA and 28 mm for hylan G-F 20. The researchers also found a mean observed improvement of 2.5 mm for Hydros and 6.4 mm for Hydros-TA over hylan G-F 20. – by Casey Tingle
Disclosure: Petrella reports no relevant financial disclosures. See the full study for a complete list of all other authors’ relevant financial disclosures.