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Trabecular bone score may improve prediction power for osteoporotic fractures in postmenopausal women
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The use of trabecular bone scores improved the performance of lumbar spine areal bone mineral density in the prediction of vertebral osteoporotic fractures in postmenopausal women, according to this study.
In the Osteoporosis and Ultrasound Study, 2,409 ambulatory European women 55 years and older were recruited in five centers. The women were followed from 1999 to 2001. Follow-up for incident fractures was available for 1,007 women. Baseline Hologic scans from three centers was available for the assessment of the performance of trabecular bone scores (TBS). Researchers compared the performance of TBS, areal bone mineral density (aBMD) and their combination. They recorded 82 patients with incident clinical osteoporotic fractures and 46 patients with incident radiographic vertebral fractures.
For the prediction of incident clinical osteoporotic fractures, researchers found that TBS was significantly better than lumbar spine (LS) aBMD, while TBS and LS aBMD had similar predictive power for radiographic vertebral fractures. However, the combination of TBS and LS aBMD increased the performance over LS aBMD alone. The predictive power was similar to hip and femoral neck aBMD.
Researchers also found that TBS predicted incident fragility fractures similarly to LS aBMD in non-osteoporotic women.
“Confirmatory prospective studies are required before developing recommendations for the clinical use of TBS,” the researchers stated in the study. “The threshold of TBS below which recommendations for treatment can be given, needs further studies.”
Disclosure: The researchers report no relevant financial disclosures.
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