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Tumor grade seen as predictor of survival in patients with chondrosarcomas
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Researchers from the Rizzoli Orthopaedic Institute found that tumor grade was the greatest predictor of survival in patients with pelvic chondrosarcomas.
“Grade was the most important predictor of the overall survival of patients with chondrosarcomas of the pelvis,” Pietro Ruggieri, MD, PhD, and colleagues from the Rizzoli Orthopaedic Institute in Bologna, Italy, wrote in their study abstract.
Ruggieri and colleagues retrospectively analyzed 215 patients who underwent limb salvage or amputation and had a preoperative biopsy and histological diagnosis of their tumor, according to the abstract. The investigators analyzed local recurrence and survival to death in patients with and without local recurrence. The location of the tumor on the pelvis, grade, type, and stage using the Musculoskeletal Tumor Society system were also studied.
A lower overall survival was associated with dedifferentiation. Ruggieri and colleagues noted peripheral chondrosarcomas predicted survival in the univariate analysis only, while surgical margins predicted local recurrence only in the multivariate analysis. Both univariate and multivariate analyses revealed tumor grade was the most important predictor of patient survival, according to the abstract.
Disclosure: The authors have no relevant financial disclosures.
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