Chronic kidney disease associated with late AMD in Asian patients
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Key takeaways:
- Lower eGFR was associated with late AMD, even after adjusting for confounding variables.
- Presence of chronic kidney disease was also associated with late AMD.
Chronic kidney disease and compromised kidney function were significantly associated with late age-related macular degeneration, according to a pooled analysis of 10 Asian-based studies.
“By aggregating individual-level data from an extensive Asian-based consortium encompassing 10 population-based studies, we examined the associations between CKD, kidney function and AMD,” Can Can Xue, PhD, from the Singapore Eye Research Institute, and colleagues wrote in Ophthalmology. “With an overall sample exceeding 50,000 individuals, this investigation represents one of the most extensive to date in this domain.”
Researchers used individual-level data from the Asian Eye Epidemiology Consortium to conduct a pooled analysis of 10 cross-sectional, population-based studies in China, India, Japan, Korea, Russia and Singapore.
Of 51,253 participants, 9.9% had chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2. The prevalence of any AMD was 9.7%, compared with 9% for early AMD and 0.71% for late AMD. The prevalence rates for all AMDs were higher among individuals with CKD compared with those without.
Researchers also reported that lower eGFR was significantly associated with late AMD, even after adjusting for confounding variables (P < .001). Likewise, presence of CKD was significantly associated with late AMD. However, CKD and eGFR were not significantly associated with early AMD nor any AMD.
Asian population-based studies from individual-level participant data across 10 distinct Asian population-based studies, revealed significant association between compromised kidney function and late AMD,” Xue and colleagues wrote. “This finding potentially underscores the merit of AMD screening among individuals with kidney disease.”
Perspective
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Reviewing the underlying pathogenic mechanisms and genetic polymorphism of CKD reveals notable parallels with AMD, making this article highly relevant to optometrists. While the paper emphasizes a correlation between CKD and late-stage AMD, it does not establish a similar link with early-stage AMD. This prompts inquiry into whether CKD serves as a predictor for AMD progression from early to late stages — a facet unexplored in this study.
Additionally, the paper’s specificity to the Asian population limits its broader applicability and generalizability. Nevertheless, it does underscore the significance of ocular examinations for individuals with kidney disease, offering insights into potential associations between these conditions.
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