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Vitamin E may sustain ciprofloxacin release in contact lenses
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Researchers report that vitamin E loading could effectively increase the amount of ciprofloxacin binding in commercial silicone-based soft contact lenses and sustain the release time in artificial tears, according to a study in Eye & Contact Lens.
The addition of vitamin E caused a considerable increase in ciprofloxacin release time for Air Optix (Alcon), Biofinity (CooperVision) and Acuvue Oasys lenses (Johnson & Johnson Vision), compared to non-vitamin E-loaded lenses.
The three different commercial lenses were soaked in vitamin E solutions. The effect of vitamin E on ciprofloxacin loading amount and drug releasing profile was evaluated in an artificial tear.
As a hydrophobic barrier, vitamin E significantly decreased the water content of silicone-based soft contact lenses, according to researchers.
After vitamin E loading, a 5% to 18% increase was found in lens diameter in the hydrated state, whereas the lens diameter increased by 11% to 23% in the dry state.
In all lenses, vitamin E loading in a 0.2-g/mL solution caused a 27.94% to 37.08% increase in ciprofloxacin binding.
Applying vitamin E loading solutions, with 0.1 g/mL and 0.2 g/mL concentrations could effectively enhance ciprofloxacin release from 2 hours to 14 to 17 days and 30 to 33 days, respectively.
for the development of a controlled drug delivery system for ciprofloxacin, the researchers wrote. – by Abigail Sutton
Disclosure: The researchers report no relevant financial disclosures.
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