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Progression seen over long term in nearly half of patients with low-pressure glaucoma
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Glaucoma progressed after more than 8 years despite treatment in almost half of patients with low-pressure glaucoma, a study found.
The retrospective study, conducted at the Wills Eye Hospital Glaucoma Research Center, included 49 eyes of 49 patients who were followed for low-pressure glaucoma for at least 8 years. Mean follow-up was 9.3 years.
Progression was defined as worsening of both disc and visual field status.
Glaucoma progressed in 25 eyes and was stable in 24 eyes. Median patient age at diagnosis was 58 years in the group that progressed and 63 years in the stable group.
Glaucoma tended to progress in patients with thinner central corneal thickness and disc hemorrhage.
Estimated change in median deviation in visual field status each year was –0.57 dB in the progression group and –0.10 dB in the stable group (P < .0001).
Peak IOP was 17.6 mm Hg in the progression group and 15.8 mm Hg in the stable group; the between-group difference was statistically significant (P = .043).
IOP change after pupil dilation, final IOP and change in IOP from baseline were similar between the two groups.
Additionally, 48% of patients who progressed and 16.7% of patients who were stable required surgery and laser treatment; the between-group difference was not statistically significant. – by Matt Hasson
Disclosure: The authors report no relevant financial disclosures.
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Erdem E, at al. Eur J Ophthalmol. 2015;doi:10.5301/ejo.5000624.
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