Study patients report decreased symptoms with multipurpose disinfecting solution

Issue: March 2012

ByJames P. Owen, OD, FAAO

A recent study to assess the ocular safety, efficacy, patient acceptance and physician recommendation of RevitaLens OcuTec multipurpose disinfecting solution showed that users reported decreased ocular redness, burning, irritation and discomfort. In addition, clinicians observed a low rate of adverse events.

James P. Owen

The Global RevitaLens Experience and Acceptance Trial (GREAT Trial) was a multicenter, open-label, noncomparative study and included 2,979 patients from individual sites in Europe and the U.S. Inclusion criteria were patients wearing the same brand of soft contact lenses for 12 months or more and using a multipurpose disinfecting solution (MPDS) for contact lens care. Patients were a mean age of 35.9 ± 13.2 years, with a mean treatment duration of 37.5 ± 18.06 days. Silicone hydrogel lenses were worn by 74.8% of the participants; conventional hydrogel contact lenses were worn by 25.2%.

All patients underwent clinical examination based on the physician’s standard clinical practice. Severity of signs and symptoms was recorded at baseline and at the final visit about 30 days later. Participants were asked a series of questions to evaluate the degree of comfort of RevitaLens (Abbott Medical Optics).

There were no reports of ocular infection during the study. Patients noted a significant improvement in the severity of symptoms after using RevitaLens (paired t-test, P < 0.001); 93.5% found it effective in keeping their contact lenses clean and 90.2% found it effective in keeping their contact lenses feeling comfortable.

Eighty-seven percent of patients said they would use RevitaLens in the future, while 76.2% of patients surveyed noted that they preferred RevitaLens over their current MPDS. Eighty-seven percent of doctors surveyed recommend RevitaLens OcuTec MPDS.

This study shows that RevitaLens MPDS possesses high efficacy against important pathogens as well as providing wearing comfort for the patients. Participants reported comfort upon insertion of contact lenses and throughout the day while using RevitaLens. This outcome of long-lasting comfort has also been demonstrated in numerous other studies, according to Tarantino et al.

The RevitaLens OcuTec formulation maintains 99.99% biocidal efficacy against the ISO standard panel of microorganisms in addition to a broad spectrum of additional pathogens, even when exposed to partial evaporation. The interactive system of disinfecting and buffering agents works together to chemically bind proteins to prevent their attachment to the lens surface.

References:

Kilvington S, Nikolic M, Lam A, et al. Antimicrobial efficacy of contact lens care solutions and a new experimental multipurpose formulation against bacteria, fungi and Acanthamoeba. Poster presented at: British Contact Lens Association, May 2010.

Nikolic M, Kilvington S, Cheung S, et al. Survival and growth of Stenotrophomonas maltophilia in multipurpose contact lens solutions. Poster presented at: British Contact Lens Association Meeting, May 2010.

Powell CH et al. Susceptibilities of various contact lens multipurpose solutions to efficacy diminution when partially evaporated. Paper presented at: ARVO 2007. Fort Lauderdale, FL.

Powell H, Hoong L, Kilvington S, et al. Evaporation effects on the efficacy of contact lens multipurpose solutions. Poster presented at: British Contact Lens Association, May 2010.

Tarantino N, et al. Poster presented at: Academy 2010, November 2010. San Francisco, CA.

Willcox MD, Carnt N, Diec J, et al. Contact lens case contamination during daily wear of silicone hydrogels. Optom Vis Sci. 2010;87(7):456-464.

James P. Owen, OD, FAAO, is in practice at Encinitas Optometry, in Encinitas, Calif. He can be reached at (760) 521-4973 or encinitasod@gmail.com.

Disclosure: Dr. Owen is a consultant for Abbott Medical Optics.