Ocular Oncology News

Patients with iris melanoma treated with plaque radiotherapy were more likely to develop post-management glaucoma than when other conservative treatments were used, according to a speaker.

The first patient has been dosed in a phase 2 clinical trial investigating safety and efficacy of suprachoroidal administration of AU-011 as a potential treatment for primary choroidal melanoma, according to a press release.

Patients who underwent an organ transplant and were diagnosed with conjunctival squamous cell carcinoma presented with greater tumor thickness and larger basal diameter compared with patients who did not undergo an organ transplant.

The majority of patients with choroidal melanoma treated with AU-011 have maintained vision and experienced tumor control and reduced growth rate, according to interim results of a phase 1b/2 open-label clinical trial.

Clinical outcomes for patients with malignancies have improved in the past decade, in part due to the emergence of VEGF inhibitors.

PHILADELPHIA — Ocular melanoma patients who received prophylactic bevacizumab with plaque radiotherapy experienced significantly better visual acuity outcomes than control patients who did not receive bevacizumab, according to a speaker here.

Patients treated with iodine-125 brachytherapy for uveal melanoma could have a substantial risk for developing open-angle or neovascular glaucoma.

As a retina specialist, my busy private practice sees a wide spectrum of the patient population. We have a significant number of patients on therapies for systemic conditions. These conditions can have multiple side effects on the eye; therefore, we are required to continually monitor these patients for toxicities.

Drugs that treat systemic diseases can be lifesaving, but when these drugs lead to poor ocular health or vision, the treatment paradigms can be difficult to balance. When a systemic disease and its treatment are negatively affecting vision, hard choices need to be made.

An 83-year-old woman with diet-controlled type 2 diabetes presented to Lahey Medical Center as a transfer from Bermuda for presumed orbital cellulitis.