Ocular Oncology News

AU-011, an investigational, first-in-class targeted therapy for ocular melanoma treatment, was granted fast track designation by the FDA, according to a press release from Aura Biosciences.

NEW YORK — Some clinical trials evaluating standard melanoma immunotherapies have been disappointing for metastatic uveal melanoma, Alexander Shoushtari, MD, assistant attending physician at Memorial Sloan Kettering Cancer Center, said at HemOnc Today Melanoma and Cutaneous Malignancies.

A study carried out at Retina Consultants of Houston and Houston Methodist Hospital confirmed the safety of fine needle aspiration biopsy in patients with uveal melanoma. No tumor cells were found in the scleral tract of the needle or adjacent pars plana when histopathological analysis was performed after enucleation.

PHILADELPHIA — Imaging studies should be completed before enucleation or evisceration surgeries to rule out unsuspected tumors, a speaker said at the Wills Eye Conference.

PHILADELPHIA – Conjunctival tumors in children statistically are more often benign than those in adults and can be differentiated by using a set of markers, a speaker said at the Wills Eye Conference.

The FDA has cleared an investigational new drug application for light-activated AU-011 in ocular melanoma, allowing clinical testing to begin, according to a press release from Aura Biosciences.

In a study of cases spanning nearly 40 years, only 3% of conjunctival tumors in children were malignant.

The combination of systemic vincristine, topotecan and carboplatin with aggressive focal therapies improved ocular salvage and preserved vision in patients with advanced retinoblastoma, according to study results published in the Journal of Clinical Oncology.

Dirofilaria repens is an endemic parasite in Mediterranean countries that mostly affects animals. Dirofilaria is a genus of the family Onchocercidae of the super family Filarioidea, order Spirurida in the subphylum Nematoda. Rarely, it can infect humans, causing inflammatory subcutaneous swelling. Human ocular dirofilariasis is sporadically reported in different parts of the world. The species affecting humans are D. immitis, D. repens, D. striata, D. tenuis, D. ursi and D. spectans. The most common presentation is an inflammatory swelling of the ocular adnexa. We report a non-inflammatory presentation of dirofilariasis in the lid mimicking as lipoma in a patient on cancer chemotherapy.

Dirofilaria repens is an endemic parasite in Mediterranean countries that mostly affects animals. Dirofilaria is a genus of the family Onchocercidae of the super family Filarioidea, order Spirurida in the subphylum Nematoda. Rarely, it can infect humans, causing inflammatory subcutaneous swelling. Human ocular dirofilariasis is sporadically reported in different parts of the world. The species affecting humans are D. immitis, D. repens, D. striata, D. tenuis, D. ursi and D. spectans. The most common presentation is an inflammatory swelling of the ocular adnexa. We report a non-inflammatory presentation of dirofilariasis in the lid mimicking as lipoma in a patient on cancer chemotherapy.