VIDEO: Choroidal macrophages could be target for AMD treatments
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SEATTLE — In this video, Eleonora M. Lad, MD, PhD, vice chair of ophthalmology clinical research at Duke Health, continues to discuss highlights from the ARVO annual meeting.
Lad focuses on the importance of the collaborative nature of the MACUSTAR project in Europe before discussing advancements in understanding of choroidal macrophages.
Certain choroidal macrophages were found to be depleted in patients with age-related macular degeneration, Lad said.
“They’re shown to play a critical role. It’s a unique population that might be implicated in lipid metabolism and peripheral homeostasis,” Lad said.
More research is needed, but this development could lead to therapies that target such macrophages.
Reference:
- Fortmann, S, et al. FOLR2+ choroidal macrophages are a homeostatic lipid handling subset of phagocytes that are depleted in AMD. Presented at: Association for Research in Vision and Ophthalmology meeting; May 5-9, 2024; Seattle.
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