Cross-linking shows efficacy in recurrent corneal erosion syndrome
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FRANKFURT, Germany — Corneal cross-linking proved to be an effective alternative treatment for recurrent corneal erosion syndrome and offered relief from symptoms without recurrence at 1 year.
Recurrent corneal erosion syndrome is a common condition caused by weakened adhesion of the corneal basement membrane to the epithelium, according to the study abstract.
“So, why don’t we use cross-linking to strengthen the connections between the basement membrane and the epithelium?” Olga Diego Navarro, MD, said at the ESCRS winter meeting.
A retrospective study, carried out at Complejo Hospitalario Universitario de Albacete, Spain, evaluated this novel off-label use of CXL and included 10 eyes of patients older than 18 years with no response to conservative treatment and 1 year of follow-up. The Dresden protocol was used in three eyes, and an accelerated protocol was used in seven eyes.
“In our population, the syndrome was more common in females around 46 years old, and main risk factors were epithelial basement membrane dystrophy (70%) and previous trauma (30%),” Diego Navarro said.
Significant reduction of pachymetry was observed after the treatment, from 542.8 µm preop to 502.8 µm postop (P < .05). The endothelium was not affected. Refraction showed a shift toward hyperopia of about 1 D, consequent to the flattening of the cornea, but best corrected visual acuity was unchanged.
There were no complications and no recurrences at 1 year of follow-up.
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Diego Navarro O, et al. New cross-linking applications: Off-label alternative use for recurrent corneal erosion syndrome. Presented at: ESCRS winter meeting; Feb. 15-18, 2024; Frankfurt, Germany.
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