Susvimo maintains vision in wet AMD through 96 weeks
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FORT LAUDERDALE, Fla. — Susvimo was noninferior to monthly ranibizumab and provided comparable vision and controlled retinal thickness through 96 weeks, according to data from the Archway trial.
At the Retina World Congress, Aleksandra Rachitskaya, MD, presented end-of-study results from the phase 3 trial, which explored the safety and efficacy of Susvimo (ranibizumab injection, Genentech) in patients with neovascular age-related macular degeneration.
“The Port Delivery System (PDS) is a continuous intravitreal delivery of a customized formulation of ranibizumab,” she said. “The PDS was recently approved by the FDA for the treatment of neovascular AMD in adults who have previously received and responded to two or more anti-VEGF injections.”
Susvimo previously showed noninferiority to monthly ranibizumab, reaching the primary endpoint of change in best corrected visual acuity from baseline averaged over weeks 36 and 40.
Rachitskaya focused on secondary endpoints such as change in BCVA from baseline to certain timepoints, including an average of weeks 60 and 64 and weeks 88 and 92.
Visual outcomes observed at week 40 were maintained through 96 weeks of treatment, Rachitskaya said. Looking at weeks 60 and 64 and weeks 88 and 92, Susvimo was noninferior to monthly ranibizumab. The PDS implant also provided similar control of retinal thickness compared with monthly ranibizumab.
The PDS safety profile was unchanged from the primary analysis. Rachitskaya said systemic safety results were comparable with those seen in monthly ranibizumab.
“It also reduced treatment burden,” she said. “Through each of the four PDS treatment intervals, 95% of PDS patients did not receive supplemental ranibizumab treatment.”
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Rachitskaya A. End-of-study results from the phase 3 Archway trial of the Port Delivery System with ranibizumab in neovascular age-related macular degeneration. Presented at: Retina World Congress; May 12-15, 2022; Fort Lauderdale, Fla.
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