Radiotherapy may not improve outcomes in uveal melanoma with extraocular extension
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There was no significant difference in survival in eyes that underwent enucleation for uveal melanoma with extraocular extension between postoperative orbital external beam radiotherapy vs. observation, according to a poster presentation.
“The purpose of the present study was to improve evidence-based management of patients with [extraocular extension] from [uveal melanoma] undergoing enucleation,” Kelsey A. Roelofs, MD, FRCSC, and colleagues wrote in the poster presented at the virtual American Society of Ophthalmic Plastic and Reconstructive Surgery annual meeting.
The retrospective study assessed patients who had an extrascleral or extraocular extension from uveal melanoma treated with enucleation at Moorfields Eye Hospital between 1997 and 2019, including 29 patients (mean age, 69 years; mean thickness, 0.7 mm) monitored with observation and 22 treated with external beam radiotherapy (mean age, 66 years; mean thickness, 8.5 mm).
Researchers contacted all patients who did not have a date of death listed in their EHR via telephone to verify vital status and orbital recurrence. Survival was the study’s primary outcome of interest.
There was no significant difference in survival between patients who received external beam radiotherapy vs. those who were monitored, the researchers wrote. They also wrote that there were “no clinically apparent orbital recurrences in either group.”
“Our findings suggest that cases with relatively small [extraocular extension] of less than 5 mm in thickness, with complete excision from the orbital contents, can be safely observed without the need for adjuvant radiotherapy,” the researchers wrote.
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Roelofs KA, et al. Adjuvant external beam radiotherapy following enucleation of eyes with extraocular extension from uveal melanoma. Presented at: American Society of Ophthalmic Plastic and Reconstructive Surgery annual meeting; Nov. 20-22, 2020 (virtual meeting).
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