Black patients at higher risk for graft failure after endothelial keratoplasty
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A large national study found Black patients were at a higher risk for graft failure after endothelial keratoplasty, according to a poster at the virtual Women in Ophthalmology Summer Symposium.
“Previously known risk factors include indication for surgery and ocular comorbidities such as glaucoma and prior glaucoma surgery. However, in our analysis, even when adjusting for these factors, we found that race, particularly patients of Black/African American race, were at increased risk of failure. We know that racial disparities exist in many aspects of health and that the COVID pandemic has shown additional light on these disparities,” poster co-author Divya Srikumaran, MD, told Healio/OSN.
The researchers assessed graft failure rates and risk factors by performing a retrospective analysis of the IRIS Registry. They evaluated 23,584 endothelial keratoplasty procedures from 2013 to 2018 that had a minimum follow-up of 1 year. Data were adjusted for surgical indication, comorbidities, demographics and complications.
The adjusted hazard ratio for Black patients for graft failure was 1.33 (95% CI, 1.19-1.49). Additional factors that increased graft failure rates were prior glaucoma surgery, prior graft failure, bullous keratopathy, history of glaucoma and postoperative rebubble.
“To date, relatively less is known about racial disparities with regards to endothelial keratoplasty outcomes, and future studies are now needed to further understand the underlying cause and develop strategies to address these disparities,” Srikumaran told Healio/OSN.
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Srikumaran D, et al. Risk factors for graft failure after endothelial keratoplasty: An IRIS Registry analysis. Presented at: Women in Ophthalmology Summer Symposium; Aug. 21-23, 2020 (virtual meeting).
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