This article is more than 5 years old. Information may no longer be current.

Several factors associated with early and long-term success of DSAEK

Add topic to email alerts

Receive an email when new articles are posted on

Please provide your email address to receive an email when new articles are posted on .

Subscribe

Added to email alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

Back to Healio

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

Back to Healio

Mark A. Terry

CHICAGO — Diabetic graft donors, pseudophakic/aphakic corneal edema and operative complications were the three biggest predictors of graft failure in Descemet’s stripping automated endothelial keratoplasty, according to a speaker here.

“DSAEK success in the early and entire postoperative period is more likely when the donor did not have diabetes, where there were no operative complications and in the longer-term postoperative period in recipients with Fuchs’ dystrophy compared to those that had pseudophakic or aphakic corneal edema,” Mark A. Terry, MD, said at the American Academy of Ophthalmology meeting.

A multicenter, randomized, non-inferiority clinical trial included 70 surgeons using different surgical techniques, with 1,330 DSAEK procedures overall.

Primary failures were defined as cloudy corneas on the first postoperative day that did not clear or required a regraft by 8 weeks with no surgical complications. Early failures were defined as cloudy corneas on the first postoperative day that did not clear or required a regraft by 8 weeks associated with surgical complications, and late failures occurred after 8 weeks postoperatively. Overall, the 3-year graft success rate was 94.1%. Among the 79 failures in the study, 45 were primary or early failures and 34 were late failures.

Eyes with diabetic donors had a 90.3% success rate at 3 years, those with pseudophakic/aphakic corneal edema had an 83.7% success rate, and those with operative complications had a 79.5% success rate.

Terry said there was no evidence to suggest age, preoperative endothelial cell density, lenticule diameter and preservation time were risk factors for graft failure. – by Robert Linnehan

Reference:

Terry MA. Factors associated with graft success in the cornea preservation time study. Presented at: American Academy of Ophthalmology meeting; Oct. 27-30, 2018; Chicago.

Disclosure: Terry reports he receives grant support from the National Eye Institute.