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Fluorescein angiography, high magnification detect retinal changes in Zika patients

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Camila V. Ventura

VANCOUVER, British Columbia — High magnification and fluorescein angiography detected retinal and vasculature changes in a consecutive case series of children diagnosed with Zika infection, according to a speaker here.

“Fluorescein angiography was useful in detecting the discrete retinal defects, which are unspecific for congenital Zika syndrome, but they might explain the high visual impairment rates in these children. Also, this study has shown that the retinal vasculature in congenital Zika syndrome may be affected, and this might be caused by the direct aggression of the virus on these vessels,” Camila V. Ventura, MD, PhD, said at the American Society of Retina Specialists annual meeting.

The consecutive case series included 6 children, all of whom had clinical features of Zika, positive serology for Zika in the cerebrospinal fluid (CSF) and negative serology for other infectious disease in the CSF. Researchers evaluated each patient with a dilated fundus examination, color fundus imaging, and fluorescein angiography (FA) imaging.

The fundus examination and wide-angle imaging found 58% of the eyes in the cohort had retinal and retinal vasculature findings. However, high magnification imaging found 100% of eyes had retinal findings and 58% had retinal vasculature findings. Additionally, FA imaging alone found all eyes in the cohort to have retinal findings and retinal vasculature findings, Ventura said.

“High magnification and FA imaging are useful tools in the detection of retinal and retinal vasculature changes in congenital Zika syndrome,” she said. – by Robert Linnehan

Reference: Ventura CV. High magnification photography and fluorescein angiography in infants with congenital Zika syndrome. Presented at: American Society of Retina Specialists annual meeting; July 20-25, 2018; Vancouver, British Columbia.

Disclosure: Ventura reports no relevant financial disclosures.