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NSAIDs, steroids boost short-term results of laser trabeculoplasty

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NEW YORK — Data from the Steroids After Laser Trabeculoplasty trial showed both NSAIDs and steroids resulted in statistically significant short-term IOP lowering compared with a placebo, according to a speaker here.

“Both NSAIDs and steroids resulted in an approximate twofold improvement of IOP compared to placebo in a short-term result. So, practically, short-term postop use of NSAIDs or steroid drops may improve pressure after SLT in the short term,” Sylvia Groth, MD, said at the American Glaucoma Society annual meeting.

The double-masked, randomized, placebo-controlled, dual-center, multi-surgeon trial included 96 eyes, all pretreated with one drop of apraclonidine immediately before laser treatment. Twenty-eight eyes received NSAIDs, 37 received steroids, and 31 received saline tears after surgery. At baseline, patients in all groups were similar with regard to demographics and IOP.

At 12 weeks, IOP decreased a mean 6.4 mm Hg (P = .002) in the NSAID group and a mean 5.2 mm Hg in the steroid group (P = .02), both statistically significant decreases compared with the saline placebo group, which decreased a mean 3 mm Hg.

“A future direction for this study could be to determine if applying both drops could have a synergistic effect,” Groth said. – by Robert Linnehan

Reference:

Groth S. Steroids after laser trabeculoplasty (SALT) trial: Impact of short-term use of anti-inflammatory treatment on the efficacy of SLT. Presented at: American Glaucoma Society annual meeting; Feb. 28 to March 4, 2018; New York.

Disclosure: Groth reports no relevant financial disclosures.