This article is more than 5 years old. Information may no longer be current.
Multicolor imaging detects features of AMD
Click Here to Manage Email Alerts
Specificity values were high when multicolor retinal imaging was used to detect features of age-related macular degeneration, according to a study.
Researchers evaluated 105 eyes with gradable images for comparison of features of age-related macular degeneration (AMD). The observational case series included images from 26 patients in the pilot phase of the Northern Ireland Cohort for the Longitudinal Study of Ageing and from 33 patients at hospital clinics. The researchers graded early and late AMD features, such as hard drusen, soft drusen and pigment clumping, on color fundus photography (Canon CX-1 Digital Fundus Camera) and multicolor retinal imaging (Heidelberg Spectralis SD-OCT/SLO).
Researchers used color fundus photography as the comparator for evaluating AMD features. The multicolor imaging sensitivity ranged from 69.7% for detection of pigment clumping to 100% for detecting atrophy, fibrosis and non-geographic atrophy hypopigmentation. For color fundus photography, the sensitivity for detection of pigment clumping was 76.7% and for non-geographic atrophy hypopigmentation was 77.8%. Color fundus photography sensitivity for detection of reticular drusen was least sensitive at 27.8%.
Early AMD features were detected more frequently with multicolor imaging, but late AMD features were detected more frequently with color fundus photography.
When differences were noted between the two, “corresponding OCT images showed that on most occasions, the appearances were consistent with the grading made on [multicolor imaging], with the exception of hemorrhages and non-GA hypopigmentation,” the authors wrote. – by Robert Linnehan
Disclosures: The researchers report no relevant financial disclosures.
Click Here to Manage Email Alerts