Ophthalmic diffuse large B-cell lymphoma survival affected by different factors

Several factors, including increased age and location, can influence overall survival rates in patients with ophthalmic diffuse large B-cell lymphoma, according to a study.

Researchers evaluated the November 2016 submission of the National Cancer Institute’s Surveillance, Epidemiology, and End Results database for patients diagnosed with diffuse large B-cell lymphoma (DLBCL) from Jan. 1, 1973, to Dec. 31, 2014. The retrospective analysis included 396 patients and evaluated disease location, patient demographic characteristics and treatment modalities, and how these factors affected overall patient survival.

Using a Cox proportional hazard regression model, researchers found patients aged older than 60 years were at a statistically significant increased risk for death (P < .001) when compared with those 60 years of age and younger. Location also affected survival, according to Kaplan-Meier survival analyses. Patients with primary vitreoretinal lymphoma (PVRL) had a 5-year overall survival rate of 41.4% and those with ocular adnexal (OA)-uveal DLBCL had a 5-year overall survival rate of 59.1%. Patients with PVRL had a lower average survival rate of 38 months compared with OA-uveal disease of 96 months.

Patients with PVRL, uveal or OA disease had a higher average survival rate of 84 months compared with 46 months for patients with primary DLBCL occurring outside the central nervous system and ophthalmic regions. – by Robert Linnehan

Disclosures: The authors report no relevant financial disclosures.

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Source:

Ahmed AH, et al. JAMA Ophthalmol. 2017;doi:10.1001/jamaophthalmol.2017.3286.