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Mobility test tracks vision changes in inherited retinal dystrophies
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A novel multi-luminance mobility test accurately distinguished normal-sighted subjects from visually impaired subjects with inherited retinal dystrophies and tracked vision declines over time.
Researchers enrolled 62 subjects in the prospective, observational study. Normal-sighted and visually impaired subjects completed a multi-luminance mobility test three times over the course of 1 year. Subjects used individual eyes and both eyes during the test, while researchers evaluated accuracy and speed compared with visual acuity and field. Subjects followed arrows on the mobility course and avoided obstacles in or adjacent to their paths. The subjects were evaluated at different light levels to determine the lowest level they could complete the course.
All control subjects passed all test attempts, but visually impaired subjects had a wide variety of performances, with some declining over the year. Researchers also found that performance declined if a subject’s visual acuity and field fell below a certain threshold.
“All the visually impaired subjects who had VA loss greater than 0.5 logMAR units showed a range of accuracy performance; those with greater than 2 logMAR units loss had very high (poor performance) accuracy scores,” the researchers wrote.
Additionally, eight visually impaired subjects had a worsening test change score of –1 or –2 over the 1-year observation period. – by Robert Linnehan
Disclosures: Chung reports he is an employee of Spark Therapeutics, holds equity in the company and is an inventor on a submitted patent related to the multi-luminance mobility test. Please see the study for all other authors’ relevant financial disclosures.
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