July 24, 2017
5 min read
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YAG laser vitreolysis improves symptomatic vitreous floaters

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YAG laser vitreolysis was associated with a better improvement in vitreous floater symptoms than a sham procedure, according to study findings.

Perspective from Inder Paul Singh, MD

Researchers conducted a masked, sham-controlled, randomized clinical trial in 52 eyes of 52 patients. The study included 36 patients and 16 controls at a single center between March 25, 2015, and Aug. 3, 2016.

At 6 months, 54% of patients in the YAG laser group experienced symptomatic improvement compared with 9% of controls (P<.001). The study procedure also yielded a greater improvement in the 10-point visual disturbance score than the sham procedure, 3.2 vs. 0.1 (P<.001).

Significantly or completely improved symptoms were reported by 53% of patients in the YAG laser arm and 0% of those in the sham arm (P<.001).

A number of parameters on the National Eye Institute Visual Function Questionnaire-25 were improved in the YAG laser group compared with the sham procedure, including general vision (P=.04), peripheral vision (P=.04), role difficulties (P<.001) and dependency (P=.03).

Neither group had a significant change in best corrected visual acuity.

Adverse event rates were similar between the two arms. – by Rob Volansky

Disclosures: The authors report no relevant financial disclosures.