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Older patients at higher risk for class 2 uveal melanoma tumors
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BOSTON — Class 2 uveal melanoma tumors are associated with older age, tumor size, ciliary body involvement and exudative retinal detachment, according to a poster presented at the American Society of Retina Specialists meeting.
Duncan Berry, MD, and colleagues presented the multi-institutional study, which consisted of 379 patients with posterior uveal melanoma treated with I-125 plaque brachytherapy. Patients had concurrent tumor biopsies submitted for gene expression profile, which classified 263 patients as having class 1 tumors and 113 as having class 2 tumors.
Patients with class 2 tumors were an average of 63.7 years of age, a statistically significant difference than the average of 60 years for patients with class 1 tumors (P = .002).
Other statistically significant differences between patients with class 1 tumors vs. patients with class 2 tumors were as follows, respectively: tumor height, 3. 5 mm vs. 5 mm (P < .001); largest basal diameter, 12 mm vs. 13.2 mm (P < .001); ciliary body involvement, 13% of tumors vs. 27% of tumors (P = .007); exudative retinal detachment, 29% of tumors vs. 51% of tumors (P < .001).
The authors found statistically significant differences between class 1A and class 1B tumors with regard to mean age, 61.6 years vs. 55.5 years, and presence of subretinal fluid, 64% of tumors vs. 80% of tumors, respectively. Consequently, there was an even larger difference in patient age between patients with class 2 tumors vs. those with class 1B tumors (P < .001). – by Robert Linnehan
Reference:
Berry D, et al. Relationship of clinical features and baseline tumor size with gene expression profile status in uveal melanoma: A multi-institutional study. Presented at: American Society of Retina Specialists 35th Annual Meeting, Aug. 11-15, 2017; Boston.
Disclosure: Berry reports no relevant financial disclosures.