New biomechanical index may help detect keratoconus

Issue: January 2017

More than 98% of cases were correctly classified as being healthy or keratoconic using the Corvis Biomechanical Index, a new tool to help diagnose keratoconus, a study found.

The multicenter retrospective study included 329 patients from the Vincieye Clinic in Milan, Italy, and 329 patients from the Rio de Janeiro Corneal Tomography and Biomechanics Study Group in Rio de Janeiro, Brazil. Researchers used the Corvis ST tonometer (Oculus) to determine 16 dynamic corneal response parameters for each patient and evaluated the parameters with the Corvis Biomechanical Index (CBI) to separate healthy and keratoconic eyes.

The index successfully classified 98.8% of the eyes as healthy or keratoconic. Specificity was 98.4%, and sensitivity was 100%.

“Following the determination of the optimum parameter combination of the CBI, its diagnostic capability in distinguishing between normal and keratoconic eyes was assessed. The multivariate diagnostic model created showed high sensitivity and specificity with an overall [area under the curve] of 0.990. The CBI correctly classified more than 98% of the cases in both datasets,” the study authors wrote. – by Robert Linnehan

Disclosure: Vinciguerra reports he is a consultant for Oculus. Please see the full study for all other authors’ relevant financial disclosures.

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Source:

Vinciguerra R, et al.J Refract Surg . 2016;doi:10.3928/1081597X-20160629-01.