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Application of whole blood before staining improves outcomes of macular hole surgery
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Application of whole blood followed by brilliant blue staining of the internal limiting membrane allowed earlier and better visual rehabilitation in macular hole surgery than conventional brilliant blue staining, a study found.
“[This] could be attributed to earlier photoreceptor regeneration as evidenced by inner segment/outer segment junction continuity and increase in outer foveal thickness,” the study authors, from Guru Nanak Eye Centre in New Delhi, India, said.
The randomized controlled trial included 60 eyes of 60 patients who underwent macular hole surgery with brilliant blue staining using autologous heparinized whole blood (group A) or brilliant blue staining without blood (group B). Whole blood was applied to the area of the macular hole in group A before brilliant blue dye stained the internal limiting membrane.
Clinical assessment and spectral-domain OCT were performed at baseline, 3, 6 and 16 weeks after surgery, and 6 months after surgery.
Best corrected visual acuity improved significantly in group A at 3, 6 and 16 weeks and 6 months (P < .001). In group B, BCVA decreased at 3 weeks but improved significantly at 6 and 16 weeks and 6 months (P < .001).
BCVA was significantly better in group A than in group B at 3 weeks (P < .001), 6 weeks (P < .001), 16 weeks (P = .004) and 6 months (P = .046).
Inner segment/outer segment junction continuity was greater in significantly more eyes in group A than in group B. Outer foveal thickness was significantly greater in group A at 3 and 6 weeks. – by Matt Hasson
Disclosure: The authors report no relevant financial disclosures.
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