Inotek initiates phase 2 trial for fixed-dose combination of trabodenoson, latanoprost
Inotek Pharmaceuticals has initiated a phase 2 dose-ranging trial of a fixed-dose combination of trabodenoson and latanoprost for the treatment of patients with ocular hypertension or primary open-angle glaucoma, the company announced in a press release.
The randomized, double-masked trial will include approximately 165 patients with an IOP between 25 mm Hg and 34 mm Hg. Patients will receive various topical combinations of trabodenoson and latanoprost or latanoprost alone over 8 weeks.
“Trabodenoson is designed to restore the eye’s natural pressure by increasing aqueous humor outflow via the trabecular meshwork, the primary outflow apparatus of the eye and a site of pathology in glaucoma,” Rudolf Baumgartner, MD, chief medical officer of Inotek, said in the release.
The company expects to announce data from the trial in 2017.