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In France, use of intracameral antibiotics increases while cases of acute postoperative endophthalmitis decrease
Increased use of intracameral antibiotic injections yielded a decreased incidence of acute postoperative endophthalmitis after phacoemulsification over a 10-year period, according to a study in France.
Investigators used data from a national administrative database in France to examine not only the incidence of acute postoperative endophthalmitis but also the use of cefuroxime injection and the number of phacoemulsification cataract surgeries conducted.
The retrospective study included 6,371,242 eyes of 3,983,525 patients who underwent phacoemulsification in France from 2005 to 2014. Results showed an increase of 52.9% in the number of surgeries performed, from 495,765 in 2005 to 757,993 in 2014, and a decrease by nearly half in the incidence of postoperative endophthalmitis, from an overall incidence rate of 0.145% to 0.053% over the same period.
Multivariate analysis showed a statistically significant association between intracameral antibiotic injection and reduced rate of acute postoperative endophthalmitis (P < .001). The drug predominantly used was presumed to be cefuroxime, although the specific drug was not identified in the database, according to the authors.
Statistically significant factors associated with increased risk for acute postoperative endophthalmitis were posterior capsule rupture, combined surgery and male gender, all P < .001. Mean incidence of acute postoperative endophthalmitis in the 10 years was 0.105%. – by Kate Sherrer
Disclosure: Creuzot-Garcher reports receiving fees from Alcon, Allergan, Bausch + Lomb, Bayer, Horus, Novartis and Théa and grants from Bausch + Lomb, Horus and Théa.
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Creuzot-Garcher C, et al. Ophthalmology. 2016;doi:10.1016/j.ophtha.2016.02.019.