Intravitreal diclofenac may improve visual acuity in eyes with macular edema due to BRVO

Intravitreal diclofenac may improve best corrected visual acuity and decrease central macular thickness in eyes with macular edema related to branch retinal vein occlusion, a study found.

In the prospective study, 15 eyes of 15 patients received a single 500 µg/0.1 mL intravitreal dose of diclofenac injected with a 27-gauge needle in the inferotemporal quadrant 3.5 mm posterior to the limbus in pseudophakic eyes and 4 mm posterior to the limbus in phakic eyes.

Best corrected visual acuity, IOP, fundus fluorescein angiography and central macular thickness were assessed for 3 months.

BCVA improved in 80% of eyes after treatment.

Mean visual acuity improved significantly, from 0.115 before injection to 0.356 at 3 months (P = .002). The mean improvement was 2.2 lines. Visual acuity improved three or more lines in six eyes (40%). No patient had a decrease in visual acuity at any time point.

Mean central macular thickness decreased significantly, from 453.2 µm before injection to 350.47 µm at 1 month and 340.47 µm at 3 months (both P = .001).

Mean IOP was 16.4 mm Hg before injection and 16.6 mm Hg at 3 months; the difference was not statistically significant.

No signs of cataract progression were seen in the 12 phakic eyes. – by Matt Hasson

Disclosure: The authors report no relevant financial disclosures.

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Source:

Seth A, et al. Ophthalmic Surg Lasers Imaging Retina. 2016;doi:10.3928/23258160-20160126-08.