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Intracameral injections effective in antibiotic prophylaxis of endophthalmitis
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WAIKOLOA, Hawaii — Intracameral injections have shown to be an effective method in the antibiotic prophylaxis of endophthalmitis following cataract surgery, according to a speaker here.
“Endophthalmitis is obviously is a topic that we are all concerned about, and we are all adept at many of the risk factors,” Francis S. Mah, MD, said in a presentation at Hawaiian Eye reviewing the most recent literature regarding endophthalmitis. “Some of these papers were more recent and help us to fill out what potentially might have changed or might be current as far as our knowledge.”
Francis S. Mah, MD
According to research conducted by Lisa J. Herrinton, PhD, and colleagues, intracameral injections have shown to be the most effective method for preventing endophthalmitis.
“Interestingly, there was no statistical difference between gatifloxacin or ofloxacin,” Mah said. “There was a big statistical difference with aminoglycosides. Aminoglycosides really did not provide any coverage. It was almost like using no antibiotic, so you definitely do not want to use aminoglycosides,” Mah said.
Results from a study in Japan in 2013 from Kazuki Matsuura, MD, and colleagues showed that administration of intracameral moxifloxacin (50 g/mL to 500 g/mL) decreased the risk of endophthalmitis threefold, Mah said.
In another study that was published in 2015, Sloan W. Rush, MD, and colleagues, found that routine administration of intracameral vancomycin significantly decreased the incidence of postoperative endophthalmitis following cataract surgery, Mah said.
“Research should be continued into the optimal combination of drug and delivery method to eliminate postoperative infection and inflammation, and exploration of well-tolerated low-cost, biocompatible devices for the sustained intracameral antibiotic release is an exciting area of research,” he concluded. – by Nhu Te
Reference:
Mah F. Infectious endophthalmitis: Current trends. Presented at: Hawaiian Eye 2016 meeting; Jan. 19, 2016; Waikoloa, Hawaii.
Disclosure: Mah has relevant financial interests with Alcon, Allergan, Abbott Medical Optics, Bausch + Lomb, Valeant, CoDa, ForSight, Ocular Science, Ocular Therapeutix, Omeros, PolyActiva, Shire and TearLab.