Improved topography, wavefront parameters sustained up to 7 years after cross-linking

Issue: January 25, 2016

Corneal topography and wavefront parameters continued to improve at 5 years after corneal collagen-cross-linking, with improvement still maintained at 7 years, according to a study.

The prospective study included 36 eyes of 36 patients who underwent epithelium-off cross-linking. Mean follow-up was 7 years.

Mean Snellen equivalent uncorrected distance visual acuity improved from 0.32 preoperatively to 0.41 at 1 year, 0.39 at 5 years and 0.46 at 7 years. The improvement was statistically significant compared with baseline at 5 years (P < .005) and 7 years (P < .0005).

Mean corrected distance visual acuity improved from 0.85 preoperatively to 0.96 at 1 year (P < .02), 0.92 at 5 years (P < .04) and 0.96 at 7 years (P < .0001).

Mean spherical equivalent refractive error improved from –1.39 D preoperatively to –0.92 D at 1 year (P < .005), 0.67 D at 5 years (P < .0005) and 0.61 D at 7 years. (P < .005).

At 7 years, root mean square values, coma and secondary astigmatism decreased significantly compared with baseline (P < .0005, P < .0005 and P < .005, respectively).

Mean simulated topographic keratometry decreased 0.74 D and mean maximum keratometry decreased 0.91 D from before surgery to 7 years (both P < .0001).

There were no significant changes in corneal pachymetry. – by Matt Hasson

Disclosure: The authors report no relevant financial disclosures.

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Source:

O’Brart DPS, et al. Am J Ophthalmol. 2015;doi:10.1016/j.ajo.2015.08.023.