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Intracameral amphotericin B prevents progression of fungal corneal ulcers
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Intracameral amphotericin B resulted in faster healing of ulcers and fewer complications than conventional treatment in eyes with fungal keratitis, according to a study.
The prospective, nonrandomized study included 104 eyes of 104 patients with fungal corneal ulcers. Forty-nine eyes (group A) responded to conventional topical and systemic antifungal medication and showed signs of healing within 7 days. Fifty-five eyes (group B) did not respond within 7 days and received intracameral amphotericin B in a dose of 5 µg to 10 µg in 1 mL of 5% dextrose.
Final mean logMAR visual acuity was 1.25 in group A and 1.22 in group B. Mean visual acuity improved 0.55 in group A and 1.40 in group B.
In group B, healing with various amounts of opacification occurred in 81.48% of patients, significantly more than in group A (P < .05).
Ulcer healing occurred in 1 week to 3 weeks in 87.7% of patients in group A. Mean time to healing was 13.08 days. Complete epithelialization and healing occurred in 1 week to 2 weeks in 52.7% of patients in group B. Mean time for ulcer healing was 12.37 days.
Hypopyon disappeared in 17.12 days in group A and 13.4 days in group B.
The incidence of complications such as sloughing was significantly lower in group B than in group A (P < .05). – by Matt Hasson
Disclosure: The authors report no relevant financial disclosures.
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Sharma B, et al. Asia-Pac J Ophthalmol. 2015;doi:10.1097/APO.0000000000000107.
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