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Accelerated cross-linking stops keratoconus progression without safety concerns
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Accelerated corneal collagen cross-linking may stop the progression of keratoconus, with similar effects as the standard protocol, according to a study.
The retrospective chart review evaluated the efficacy of halting progressive keratoconus with accelerated riboflavin ultraviolet A-induced corneal collagen cross-linking at 18 mW/cm² for 5 minutes in 28 eyes.
Mean follow-up time was 21.7 months, with no complications reported.
During follow-up, there were no significant changes in mean corrected distance visual acuity, corneal astigmatism, mean keratometry, flat keratometry, steep keratometry, corneal pachymetry and corneal densitometry.
However, there was a significant reduction of maximal corneal curvature reading at the corneal apex, index of surface variance, index of vertical asymmetry and average keratometry reading of the posterior corneal surface.
“To our knowledge, this study is the first to provide long-term densitometry data after accelerated CXL,” the study authors said. “No significant differences could be seen in relation to baseline.” – by Kristie L. Kahl
Disclosure: The authors report no relevant financial disclosures.
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Alnawaiseh M, et al. Cornea. 2015;doi:10.1097/ICO.0000000000000578.
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