Ibopamine provocative test may be useful in diagnosing early stages of glaucoma

The ibopamine provocative test may detect an increased risk of glaucoma at an early stage of the disease, according to a study.

The prospective study compared 44 subjects with suspicious optic discs with 37 subjects with normal optic discs and no ocular pathology to evaluate the diagnostic ability of the ibopamine test.

Of the 81 total subjects, 26 were diagnosed with early preperimetric glaucoma.

“The average global retinal nerve fiber layer thickness and the average of the temporal, inferotemporal and inferonasal sectors were significantly lower in the group of patients with a positive ibopamine test than in those with a negative ibopamine test,” the study authors said.

The test had 78.7% sensitivity and 71.6% specificity to discriminate subjects with early glaucoma. “The positive predictive value was 61.67%, and the negative predictive value was 85.2%,” the study said.

After adjusting for age, sex, baseline IOP and pachymetry, subjects with a positive test had eight times more risk of glaucoma compared with subjects with a negative test, and those with a positive test and a suspicious optic disc had a 32.4 times higher risk of having glaucoma vs. those with a normal optic disc. – by Kristie L. Kahl

Disclosure: The authors report no relevant financial disclosures.

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Source:

Domínguez-Dueñas F, et al. J Glaucoma. 2015;doi:10.1097/IJG.0000000000000343.