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Corneal changes seen with contact lens wear after cataract surgery in Infant Aphakia Treatment Study
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The use of extended-wear contact lenses after cataract extraction in infants may lead to increased endothelial cell density, coefficient of variation of cell area and central corneal thickness, according to the Infant Aphakia Treatment Study.
The randomized, controlled clinical trial evaluated the treatment of unilateral cataracts, comparing 52 infants treated with aphakic contact lenses and 53 infants treated with primary IOL implants vs. fellow eyes at the 5-year examination.
Treated eyes had greater endothelial cell density compared with fellow eyes by an average of 427 cells/mm2 in the contact lens group, but there was no difference between treated eyes and fellow eyes in the IOL group.
In the contact lens group, mean endothelial cell density was 3,893 cell/mm2 with 72% of hexagonal cells compared with 3,470 cells/mm2 with 76% of hexagonal cells in the IOL group; mean coefficient of variation of cell area was 27 vs. 24, respectively; and mean central corneal thickness was 638 µm vs. 605 µm, respectively. The differences, except for percentage of hexagonal cells, were statistically significant.
Infants diagnosed with glaucoma had significantly lower mean cell density of 3,289 cells/mm2 compared with those not diagnosed at 3,783 cells/mm2, and infants diagnosed with glaucoma suspect had a significantly greater mean corneal thickness of 660 µm vs. those not diagnosed at 612 µm. – by Kristie L. Kahl
Disclosure: The authors report no relevant financial disclosures.
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Morrison DG, et al. Ophthalmology. 2015;doi:10.1016/j.ophtha.2015.07.011.
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