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Study: Laser anterior capsulotomy may trigger increased prostaglandin level in aqueous humor
Inflammation associated with an increased prostaglandin level in the aqueous humor correlated strongly with femtosecond laser-assisted anterior capsulotomy, according to a study.
The prospective study included aqueous humor samples from 67 patients; 19 patients underwent laser capsulotomy, 11 patients underwent laser fragmentation, 19 patients underwent a combination laser capsulotomy and laser fragmentation, and 18 patients comprised a control group that underwent conventional cataract surgery.
Aqueous humor samples were collected after pretreatment with laser capsulotomy and/or laser fragmentation and at the beginning of conventional surgery.
The mean prostaglandin level was 330.6 pg/mL in the combined capsulotomy and fragmentation group, 362.4 pg/mL in the capsulotomy group, 186.8 pg/mL in the fragmentation group and 52.5 pg/mL in the control group.
The mean prostaglandin level was significantly higher in the capsulotomy group than in the control group (P = .01). The mean level was also significantly higher in the combined capsulotomy and fragmentation group than in the control group (P = .01).
Fragmentation alone did not lead to a significant increase in prostaglandin levels.
“Optimized energy settings in combination with nonsteroidal anti-inflammatory drugs might help reduce the phenomenon of laser-induced miosis,” the study authors said. – by Matt Hasson
Disclosure: Dick reports he is a paid consultant for Abbott Medical Optics. The other authors report no relevant financial disclosures.