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Increased risk of angle closure, elevated IOP possible after anti-VEGF injection
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CORONADO, Calif. — IOP elevation may be associated with increased narrowing of nasal angle measurements after intravitreal anti-VEGF injections, according to a presentation here.
In a poster presented at the American Glaucoma Society meeting, Joanne C. Wen, MD, and colleagues studied 21 eyes of 21 patients who received intravitreal anti-VEGF injections for the treatment of neovascular age-related macular degeneration.
Mean pre- and immediate post-injection IOP was measured, as well as measurements of the anterior segment including angle opening distance, trabecular-iris space area and scleral spur angle.
The mean increase in IOP after anti-VEGF injection was 23.4 ± 11.4 mm Hg. All eyes had significant narrowing of the temporal angle opening distance and angle measurements. However, there was significantly more narrowing of the nasal angle in phakic eyes compared with pseudophakic eyes.
“Physicians performing intravitreal injections should be aware of these dynamic anterior segment changes following intravitreal injections and the possibility that there may be increased risk of angle closure with prolonged elevation of IOP in predisposed eyes,” the authors said. – by Kristie L. Kahl and Patricia Nale, ELS
Disclosure: Wen reports she is a speaker for Research to Prevent Blindness.