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Multicolor OCT system to help in diagnosis, treatment of ocular diseases
PHILADELPHIA — New developments in multicolor OCT for neuro-ophthalmology may aid in the diagnosis and treatment of diseases such as Leber’s hereditary optic neuropathy, multiple sclerosis and diabetic retinopathy, according to a presentation here.
“In a couple of years, you’re going to be able to look at patients with diabetic retinopathy and not only just look at the hemorrhage … but you’re going to be able to look at the metabolic activity of that retina,” Robert C. Sergott, MD, said at the Wills Eye Alumni Conference.
The multicolor OCT system defines local neuronal activity and produces measurements for tight coupling between neural activity and adenosine triphosphate. Mitochondrial flavoproteins are oxidized, and fluorescence follows the neuronal activity through electrical simulation, sensory and pharmacological stimuli.
“So here is one very complicated case where technology interaction with industry is helping us now treat something that wasn’t treatable before,” Sergott said.
Later this year, Wills Eye Hospital will be one of six centers worldwide to be injecting patients intravitreally with an adenovirus-linked gene to be delivered to retinal gene cells, he said. – by Kristie L. Kahl
Disclosure: Sergott reports no relevant financial disclosures.