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Therapeutic PK resolves interface infection after DSAEK
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Therapeutic penetrating keratoplasty eliminated interface infection after Descemet’s stripping automated endothelial keratoplasty, according to study findings.
The retrospective case series included 10 eyes that underwent DSAEK and subsequently developed unilateral interface infection. Seven eyes were unresponsive to conservative treatment and underwent therapeutic PK involving en bloc removal of the recipient cornea and DSAEK graft. The other three eyes were treated with fortified topical antibiotics.
The primary outcome measures were best corrected visual acuity, refractive error, histological examination and reinfection, graft rejection and graft survival rates.
Candida and Staphylococcus species were identified in three cases each; Nocardia species was identified in one case.
After a mean post-PK follow-up of 25.4 months, study results showed no recurrences of infection. Five of seven PK grafts remained clear with no rejection, according to the researchers.
BCVA was 20/20 in two eyes, 20/50 or better in four eyes, and 20/100 to 20/200 in three eyes, including two in which grafts failed within 1 year, the researchers reported.
Disclosure: The authors have no relevant financial disclosures.
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