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PROSE treatment yields significant improvement in visual acuity, function
Prosthetic replacement of the ocular surface ecosystem treatment demonstrated significant improvements in visual acuity and function in patients with a history of Stevens-Johnson syndrome / toxic epidermal necrolysis, according to study findings.
The retrospective study included 167 eyes of 86 patients with a history of chronic-phase Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) who underwent prosthetic replacement of the ocular surface ecosystem (PROSE) treatment within a 5-year period.
Main outcomes of the study were visual acuity at final follow-up and visual function based on results of the National Eye Institute 25-item Visual Functioning Questionnaire (NEI VFQ-25) at 6 months.
Medications including penicillin, sulfa, ibuprofen and lamotrigine were found to be contributory or causative in 66% of patients, according to the researchers.
Median visual acuity was 20/60 at baseline, compared with 20/25 at the completion of customization. No decline in median acuity was noted at final follow-up. Median follow-up was 16 months.
The researchers observed a significant improvement in patients’ visual function based on the NEI VFQ-25 at 6 months, from a mean of 48 points to a mean of 72 points. Additionally, an improvement was noted in patients’ self-reported general health, from a mean of 57 points at baseline to a mean of 65 points at 6 months.
Disclosures: Le and Jacobs are employees of the Boston Foundation for Sight.